Thealoz Duo®
It’s an ecosystem, not just a drop
![Blephaclean Packaging](/images/thealozduo/thealozduo.png)
Seeing is relieving
Thealoz Duo® is a unique preservative-free treatment for dry eye disease that restores the eye’s normal environment with bioprotection and osmoregulation.
Buy NowThealoz Duo® at a Glance
- Trehalose + Sodium Hyaluronate = Thealoz Duo®.
- A preservative-free treatment for dry eye disease.
- Clinically proven to stabilize tear film, reduce inflammatory markers and restore normal osmotic balance.
- Significantly alleviates symptoms and restores the ecosystem of the eye.
![](/images/thealozduo/screenshot-2022-12-08-at-42810-pm.png)
Thealoz Duo® Stabilizes the Tear Film
Extend relief of dry eyes with a thicker tear film
Relative tear film thickness over time after instillation of Thealoz Duo®, hyaluronic acid, and sodium chloride![](/images/thealozduo/thealoz-duo_charts_en.png)
Tear Film Thickness:
After 10 minutes, Thealoz Duo® increased tear film thickness by 40% more than hyaluronic acid alone (29% vs 21%)*
Residence Time:
Thealoz Duo® maintained a significant increase in tear film thickness for nearly 4 hours, almost 6 times longer than hyaluronic acid alone*
#Significant versus baseline for Thealoz Duo®
*Significant versus baseline for hyaluronic acid
Adapted from Schmidl, et al. (2015)
Thealoz Duo® Reduces Inflammatory Markers
After only 2 months inflammatory markers are reduced by an average of 58%
![](/images/thealozduo/charts_en-02.png)
Adapted from Fariselli, et al. (2018)
Thealoz Duo® Restores Osmotic Balance
Trehalose restores cell volume and stabilizes protein function, providing protection from hyperosmolarity
![](/images/thealozduo/drops-02.png)
Normal Tear:
Healthy tears with a normal salt concentration
![](/images/thealozduo/drops-03.png)
Hyperosmolarity:
Tears in dry eye with an elevated salt concentration (hyperosmolarity and decreased volume)
Thealoz Duo® Reduces Dry Eye Symptoms
Patients like the look of their new eye environment
Percentage of patients in moderate and severe OSDI classes![](/images/thealozduo/charts_en-03.png)
Adapted from Chiambaretta, et al. (2016)
After only five weeks of treatment:
- Patients with moderate to severe OSDI scores were reduced by 60%, vs. 36% with hyaluronic acid, alone.
- 1 out of 4 Thealoz Duo® patients were completely free of dry eye symptoms.
![](/images/thealozduo/60-36-split-custom.png)
![Blephaclean Packaging](/images/thealozduo/thealozduo.png)
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